Accession Number : ADA551804


Title :   The Epidemiology of Travelers' Diarrhea in Incirlik, Turkey: A Region with a Predominance of Heat-Stabile Toxin Producing Enterotoxigenic Escherichia coli


Descriptive Note : Journal article


Corporate Author : NAVAL MEDICAL RESEARCH CENTER SILVER SPRING MD ENTERIC DISEASES DEPT


Personal Author(s) : Porter, Chad K ; Riddle, Mark S ; Tribble, David R ; Putnam, Shannon D ; Rockabrand, David M ; Frenck, Robert W ; Rozmajzl, Patrick ; Kilbane, Edward ; Fox, Ann ; Ruck, Richard


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a551804.pdf


Report Date : Jan 2010


Pagination or Media Count : 9


Abstract : This study evaluated travelers' diarrhea among US military personnel on short term deployment to lncirlik Air Base. Turkey from June through September 2002. Upon reporting for care for travelers'diarrhea, subjects were enrolled into the study and completed a series of questionnaires and provided stool specimens for pathogen identification and antimicrobial susceptibility testing. Fifty-three percent of the 202 participating subjects had a pathogen isolated from their stool. Entcrotoxigenic Escherichia coli (ETEC) was the predominant pathogen (41%). followed by Campylobacter spp. ( 12%). The most common ETEC phenotype recovered was stable toxin (ST) CS6 (47% of all ETEC). Most (91.1%) of the cases presented with water diarrhea regardless of isolated pathogen. llowever, there were some differences in nongastrointestinal symptoms among subjects with Campylobacter spp. All illnesses were well managed with antibiotics with or without operamide with a median time to the last unformed stool of 9h (interquanilc range, 1- 32 h). We found no food or environmental factors associated with a differential risk of infection with a specific pathogen. Travelers'diarrhea among a US military population in and around lncirlik, Turkey, can commonly be attributed to ETEC and Campvlobacter spp. The high proponion of ST-only producing CS6 ETEC in this region highlights the pathogen 's worldwide diversity. Future studies of travelers'diarrhea in this population should adapt more novel microbiologic techniques such as polymerase chain reaction and enhanced culture methods to increase the likelihood of identifying pathogenic E. coli.


Descriptors :   *DIARRHEA , *EPIDEMIOLOGY , ANTIBIOTICS , ANTIMICROBIAL AGENTS , ESCHERICHIA COLI , IDENTIFICATION , MILITARY PERSONNEL , REPRINTS , TOXINS AND ANTITOXINS , TURKEY


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE