Accession Number : ADA551697


Title :   Combat Wound Initiative Program


Descriptive Note : Journal article


Corporate Author : WALTER REED ARMY MEDICAL CENTER WASHINGTON DC DEPT OF SURGERY


Personal Author(s) : Stojadinovic, Alexander ; Elster, Eric ; Potter, Benjamin K ; Davis, Thomas A ; Tadaki, Doug K ; Brown, Trevor S ; Ahlers, Stephen ; Attinger, Christopher E ; Andersen, Romney C ; Burris, David


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a551697.pdf


Report Date : Jul 2010


Pagination or Media Count : 8


Abstract : The Combat Wound Initiative (CWI) program is a collaborative, multidisciplinary, and interservice public-private partnership that provides personalized, state-of-the-art, and complex wound care via targeted clinical and translational research. The CWI uses a bench-to-bedside approach to translational research, including the rapid development of a human extracorporeal shock wave therapy (ESWT) study in complex wounds after establishing the potential efficacy, biologic mechanisms and safety of this treatment modality in a murine model. Additional clinical trials include the prospective use of clinical data, serum and wound biomarkers, and wound gene expression profiles to predict wound healing/failure and additional clinical patient outcomes following combat-related trauma. These clinical research data are analyzed using machine-based learning algorithms to develop predictive treatment models to guide clinical decision-making. Future CWI directions include additional clinical trials and study centers and the refinement and deployment of our genetically driven, personalized medicine initiative to provide patient-specific care across multiple medical disciplines, with an emphasis on combat casualty care.


Descriptors :   *MEDICAL RESEARCH , CASUALTIES , CLINICAL TRIALS , COLLABORATIVE TECHNIQUES , MEDICAL SERVICES , PATIENTS , REPRINTS , WARFARE , WOUNDS AND INJURIES


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE