Accession Number : ADA550810


Title :   Novel Optical Methods for Identification, Imaging, and Preservation of the Cavernous Nerves Responsible for Penile Erections during Prostate Cancer Surgery


Descriptive Note : Annual rept. 1 Mar 2008-28 Feb 2009


Corporate Author : NORTH CAROLINA UNIV AT CHARLOTTE


Personal Author(s) : Fried, Nathaniel M


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a550810.pdf


Report Date : Mar 2009


Pagination or Media Count : 52


Abstract : There is wide variability in sexual potency rates (9-86%) after prostate cancer surgery due to our limited understanding of the location of the cavernous nerves, which are responsible for erectile function. Advances in identification and preservation of these nerves would result in improved postoperative potency and patient quality of life. We hypothesize that application of three optical technologies for identification, imaging, and preservation of the nerves during prostate surgery will result in improved sexual function: (1) Laser nerve stimulation for identification, optical coherence tomography (OCT) for nerve imaging, and (3) precise laser prostate dissection for nerve preservation. Year 1 was devoted to optimization of laser stimulation parameters and comparison with electrical stimulation. We completed these tasks and then started on Year 2 aims, including assembly of a laparoscopic laser nerve stimulation probe, and improving OCT image quality for differentiating nerves and prostate. We have published our results (2 manuscripts, 5 conference proceedings, and 3 abstracts).


Descriptors :   *NERVES , *PROSTATE CANCER , FUNCTIONS , IDENTIFICATION , IMAGES , LASERS , OPTICAL PROPERTIES , PRESERVATION , PROBES , SEX , STIMULATION(GENERAL) , SURGERY , TOMOGRAPHY


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE