Accession Number : ADA550081


Title :   Vaccine Development for Biothreat Alpha Viruses


Corporate Author : ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD


Personal Author(s) : Spurgers, Kevin B ; Glass, Pamela J


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a550081.pdf


Report Date : 25 Sep 2011


Pagination or Media Count : 10


Abstract : The majority of alpha virus is non-pathogenic to humans. However, select alpha viruses can cause severe disease in humans during the course of naturally occurring epizootic outbreaks, or accidental infection of laboratory personnel. Natural infections occur through the bite of an infected mosquito. However, pathogenic alpha viruses, including Venezuelan, eastern, and western equine encephalitis viruses, have proven to be highly infectious via the aerosol route. Given this aerosol infectivity, ease of production of high-titer virus, and low infectious dose, these alpha viruses are recognized as candidates for use as biological weapons, and are classified as category B pathogens by the Centers for Disease Control and Prevention and The National Institutes of Health. There are currently no licensed vaccines to prevent alpha virus infections. Such a vaccine could protect geographically defined human populations during an epizootic, and enhance national security by serving as a deterrent to the use of these viruses as biological weapons. To address this critical need, several strategies are being pursued to develop safe, effective, and ultimately licensed vaccines for use in humans.


Descriptors :   *BIOLOGICAL WARFARE , *VACCINES , *VIRUS DISEASES , ADENOVIRUSES , CHEMICAL ORDNANCE , EASTERN EQUINE ENCEPHALOMYELITIS VIRUS , EPIZOOTIC , GROUP A ARBOVIRUSES , INFECTIOUS DISEASES , PATHOGENIC MICROORGANISMS , VENEZUELAN EQUINE ENCEPHALOMYELITIS , WESTERN EQUINE ENCEPHALOMYELITIS VIRUS


Subject Categories : Medicine and Medical Research
      Pharmacology
      Chemical, Biological and Radiological Warfare


Distribution Statement : APPROVED FOR PUBLIC RELEASE