Accession Number : ADA549835


Title :   The Oncogenic Role of WWP1 E3 Ubiquitin Ligase in Prostate Cancer Development


Descriptive Note : Final rept.


Corporate Author : ALBANY MEDICAL COLL NY


Personal Author(s) : Chen, Ceshi


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a549835.pdf


Report Date : May 2011


Pagination or Media Count : 202


Abstract : E3 ubiquitin ligase gene WWP1 is a candidate oncogene at 8q21 in human prostate because of gene amplification and over-expression. The purpose of the research is to understand the role and mechanism of WWP1 in prostate cancer development. In a four-year period, we studied functions of WWP1 and its related proteins (KLF5, PMEPA1, RNF11, ErbB4, p63 etc) in prostate and breast cancers. We demonstrated that WWP1 regulates cell proliferation, apoptosis, and migration through ubiquitinating RNF11, KLF5, ErbB4, and p63. The WWP1 interacting protein, PMEPA1, promotes AR-negative prostate cancer cell cycle through suppressing p21 expression. We published 9 research papers, 3 review articles, and 21 abstracts based on this award in the past four years.


Descriptors :   *BREAST CANCER , *PROSTATE CANCER , CELLS(BIOLOGY) , GENES , HUMANS , PROSTATE GLAND , PROTEINS


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE