Accession Number : ADA549207


Title :   Chemical Suppression of the Reactivated Androgen Signaling Pathway in Androgen-Independent Prostate Cancer


Descriptive Note : Annual rept. 1 Jul 2010-30 Jun 2011


Corporate Author : ORDWAY RESEARCH INST ALBANY NY


Personal Author(s) : Buttyan, Ralph


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a549207.pdf


Report Date : Jul 2011


Pagination or Media Count : 38


Abstract : The project studies the relationship between Hedgehog Signaling and hyperactive androgen signaling in androgen independent prostate cancer and tests the idea that Hedgehog inhibitors can block hyperactive androgen signaling leading to suppression of castration resistant tumor growth. Progress during this first annual period has established a relationship between the expression and/or activity of Hedgehog signaling proteins (Smoothened, Gli1 and Gli2) and increased androgen signaling and androgen independent (AI) growth of prostate cancer cells. Other work has linked Hedgehog signaling activity in prostate cells to the biosynthesis of testosterone. These data supports the idea that Hedgehog activity in an androgen deprived tumor both sensitizes the tumor cell to low levels of androgen and increases the local production of androgen in the tumor microenvironment and both have the potential to increase tumor growth in androgen deprived conditions. The outcomes are consistent with the idea that Hedgehog inhibitory drugs have a significant potential for treatment of advanced prostate cancer.


Descriptors :   *PROSTATE CANCER , ANDROGENS , CELLS(BIOLOGY) , CHEMICALS , CONSISTENCY , GROWTH(PHYSIOLOGY) , NEOPLASMS , PROTEINS , RESISTANCE , SIGNALS , SUPPRESSION


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE