Accession Number : ADA549137


Title :   Modulation of Stat3 Alternative Splicing in Breast Cancer


Descriptive Note : Final rept. 1 Sep 2008-31 Aug 2010


Corporate Author : SLOAN-KETTERING INST FOR CANCER RESEARCH NEW YORK


Personal Author(s) : Cartegni, Luca


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a549137.pdf


Report Date : Sep 2010


Pagination or Media Count : 27


Abstract : Stat3 is a transcription factor constitutively active in a large number of breast cancers and other tumors, where it works as a central player in the activation of multiple oncogenic pathways. We developed a method to modulate endogenous Stat3 alternative splicing using modified antisense oligonucleotides, to induce the dominant negative Stat3-beta variant in vitro and in vivo. Switching from the full length Stat3 isoform to the stat3-beta variant leads to increased tumor cell death and complete tumor regression in animal models via a novel modulatory mechanism.


Descriptors :   *BREAST CANCER , *DEATH , *ONCOGENESIS , CELLS(BIOLOGY) , IN VITRO ANALYSIS , IN VIVO ANALYSIS , MODULATION , NEOPLASMS , REGRESSION ANALYSIS , SPLICES


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE