Accession Number : ADA548987


Title :   Variations of Human DNA Polymerase Genes as Biomarkers of Prostate Cancer Progression


Descriptive Note : Annual rept. 15 Jun 2010-14 Jun 2011


Corporate Author : TULANE UNIV NEW ORLEANS LA


Personal Author(s) : Makridakis, Nick


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a548987.pdf


Report Date : Jul 2011


Pagination or Media Count : 29


Abstract : Human DNA polymerases beta, eta, and kappa are enzymes that function in repairing damaged DNA. DNA sequencing analysis of 40 prostate tumors identified somatic mutations of these genes in most patients. Biochemical analysis of the polymerase beta missense variations showed that all of these somatic mutations have functional effects. Thus, common polymerase mutations may contribute to prostate cancer progression.


Descriptors :   *PROSTATE CANCER , BIOCHEMISTRY , DEOXYRIBONUCLEIC ACIDS , ENZYMES , GENES , GROWTH(PHYSIOLOGY) , MARKERS , MUTATIONS , PATIENTS , POLYMERIZATION , TRACER STUDIES


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE