Accession Number : ADA547683


Title :   Cutaneous Leishmaniasis


Corporate Author : UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD


Personal Author(s) : Magill, Alan J ; Meyers, Wayne M ; Neafie, Ronald C ; Klassen-Fischer, Mary K


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a547683.pdf


Report Date : Jun 2011


Pagination or Media Count : 18


Abstract : The cutaneous leishmaniases include a spectrum of self healing and chronic disease forms caused by protozoan parasites of the genus Leishmania. Clinical presentations differ according to parasite burden and host immune response. Although there can be considerable overlap of clinical presentations, 5 distinct cutaneous syndromes are recognized in Leishmania infections: 1) simple or localized ulcerative or nodular cutaneous leishmaniasis (CL); 2) mucosal leishmaniasis (ML); 3) leishmaniasis recidivans (LR); 4) diffuse cutaneous leishmaniasis (DCL); and 5) post-kala-azar dermal leishmaniasis (PKDL). Immunocompromised patients may have atypical presentations. Oligoparasitic (low parasite burden) syndromes are chronic, persistent infections that follow primary ulcerative disease (ML and LR) or drug therapy for kala-azar (early forms of PKDL). Polyparasitic syndromes such as ulcerative and nodular CL, DCL, and late or nodular PKDL are characterized by a high parasite burden.


Descriptors :   *INFECTIOUS DISEASES , *LEISHMANIASIS , *PARASITES , CHEMOTHERAPY , DIFFUSION , DRUGS , HEALING , IMMUNITY , IMMUNOSUPPRESSION , MUCOUS MEMBRANES , PATIENTS , PROTOZOA , RESPONSE(BIOLOGY) , SIGNS AND SYMPTOMS , SKIN DISEASES


Subject Categories : Biology
      Microbiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE