Accession Number : ADA547285


Title :   Drug and Vaccine evaluation in the Human Aotus Plasmodium falciparum Model


Descriptive Note : Annual rept. 1 Apr 2010-30 Apr 2011


Corporate Author : PROMED TRADING S A MIAMI FL


Personal Author(s) : Obaldia, III, Nocanor


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a547285.pdf


Report Date : May 2011


Pagination or Media Count : 18


Abstract : Next generation quinoline methanol (NGQM) lead analog 8SF5MQ (WR 319689) when administered to Aotus monkeys infected with Plasmodium falciparum FVO orally at 6.25 mg/kg cleared and recrudesce but at 2.1 mg/kg had no effect over parasitemia. In contrast, mefloquine at 6.25 mg/kg cleared and cured but at 2.1 mg/kg only suppressed. Additionally, we were able to cryopreserved Aotus blood at high density parasitemias 50 x 1000 x microL for both Plasmodium vivax AMRU-1 and P. vivax SAL-1 parasites that will be used at WRAIR for in vitro culture experiments. In another series of experiments, WR621308 at 65 m/kg suppressed parasitemia in Aotus infected with P. falciparum FVO but toxic adverse effects observed in one animal stopped the experiment at a higher dose (130 mg/kg).


Descriptors :   *ANTIMALARIALS , MONKEYS , MALARIA , PLASMODIUM FALCIPARUM


Subject Categories : Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE