Accession Number : ADA545702


Title :   Biomarker Discovery and Mechanistic Studies of Prostate Cancer Using Targeted Proteomic Approaches


Descriptive Note : Annual rept. 1 Jul 2009-30 Jun 2010


Corporate Author : KENTUCKY UNIV LEXINGTON


Personal Author(s) : Kyprianou, Natasha


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a545702.pdf


Report Date : Jul 2010


Pagination or Media Count : 36


Abstract : Our findings reveal that EMMPRIN immunoreactivity was primarily detected among the glandular epithelial cells; EMMPRIN levels progressively increased with increasing age of TRAMP mice (6-27wks); with the highest detected in liver metastases. Quantitative analysis revealed that by 27-wks (an age exhibiting highly aggressive prostate tumor phenotype), EMMPRIN expression increased significantly (P=0.001). These results suggest that EMMPRIN may have diagnostic value in prostate cancer detection in advanced disease.


Descriptors :   *PROSTATE CANCER , *METASTASIS , *PROTEOMICS , DISEASES , NEOPLASMS , TARGETING , CELLS(BIOLOGY) , GROWTH(PHYSIOLOGY) , PROSTATE GLAND , GLANDS , DETECTION , QUANTITATIVE ANALYSIS , EPITHELIUM , LIVER


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE