Accession Number : ADA545698


Title :   Roles of SGK Isoform Signaling in Breast Cancer Migration and Invasion


Descriptive Note : Annual summary rept. 15 Mar 2010-14 Mar 2011


Corporate Author : HARVARD COLL CAMBRIDGE MA


Personal Author(s) : Gasser, Jessica


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a545698.pdf


Report Date : Apr 2011


Pagination or Media Count : 12


Abstract : 14. ABSTRACT My experiments indicate that Serum and Glucocorticoid regulated Kinase (SGK) proteins facilitate breast cancer invasive migration, a critical step for ultimate cancer metastasis to other organs. The activation of SGK during cellular stress conditions, such as low oxygen found within a tumor, makes this data increasingly imperative for therapeutics. The research shown here demonstrates SGK loss in highly mestatic breast cancer cell lines causes an invasive migration defect. Conversely, the overexpression of SGK isoforms in breast cancer cell lines causes an enhancement of invasive migration. These discoveries are helping to elucidate new mechanisms that can be targeted for more specific and successful therapies to block breast cancer metastasis. Known targets of SGK proteins are being examined for their contribution to the metastatic properties of breast cancer cells. These studies will determine the importance of SGK proteins as putative therapeutic targets for breast cancer motility.


Descriptors :   *BREAST CANCER , *ADRENAL CORTEX HORMONES , NEOPLASMS , TARGETS , OXYGEN , MIGRATION , CELLS(BIOLOGY) , ORGANS(ANATOMY) , METASTASIS , PROTEINS , STRESSES , THERAPY


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE