Accession Number : ADA543741


Title :   Multidisciplinary Analysis of Cyclophilin A Function in Human Breast Cancer


Descriptive Note : Annual summary 1 Mar 2008-28 Feb 2011


Corporate Author : NORTHWESTERN UNIV EVANSTON IL


Personal Author(s) : Zheng, Jiamao


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a543741.pdf


Report Date : 01 Mar 2011


Pagination or Media Count : 31


Abstract : The goal of this project was to understand how cyclophilin A (CypA) regulates the prolactin receptor (PRLr) signaling. The data have demonstrated that CypA, serving as a molecular switch via its peptidyl-prolyl isomerase (PPI) activity, binds to and regulates the function of the PRLr. Furthermore, point mutagenesis analysis has implied that a single prolyl imide bond (Pro-334) within the X-Box motif of intracellular domain of the PRLr is most likely responsible for the observed effects of CypA on the PRLr signaling. Finally, we have conducted several proof-of-concept studies that may lead to novel anti-breast cancer agents.


Descriptors :   *BREAST CANCER , *PROLACTIN , ANTIBODIES , CELLS(BIOLOGY) , GENE EXPRESSION , RECEPTOR SITES(PHYSIOLOGY) , PROTEINS , PEPTIDES , RIBONUCLEIC ACIDS


Subject Categories : Biochemistry
      Medicine and Medical Research
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE