Accession Number : ADA539009


Title :   Bacillus Anthracis Spore Interactions with Mammalian Cells: Relationship Between Germination State and the Outcome of in Vitro Infections


Descriptive Note : Journal article


Corporate Author : NAVAL MEDICAL RESEARCH CENTER BETHESDA MD


Personal Author(s) : Gut, Ian M ; Tamilselvam, Batcha ; Prouty, Angela M ; Stojkovic, Bojana ; Czeschin, Stephanie N ; van der Donk, Wilfred A ; Blanke, Steven R


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a539009.pdf


Report Date : 28 Feb 2011


Pagination or Media Count : 51


Abstract : During inhalational anthrax, internalization of Bacillus anthracis spores by host cells within the lung is believed to be a key step for initiating the transition from the localized to disseminated stages of infection. Despite compelling in vivo evidence that spores remain dormant within the bronchioalveolar spaces of the lungs, and germinate only after uptake into host cells, most in vitro studies of infection have been conducted under conditions that promote rapid germination of spores within the culture medium.


Descriptors :   *BACILLUS ANTHRACIS , *SPORES , *GERMINATION , *IN VITRO ANALYSIS , *INFECTIOUS DISEASES , *CELLS(BIOLOGY) , ALVEOLI , CULTURE MEDIA , HOSTS(BIOLOGY) , IN VIVO ANALYSIS , ANTHRAX , LUNG , BRONCHI , PROPAGATION , MAMMALS


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research
      Microbiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE