Accession Number : ADA537012


Title :   Nonequilibrium Phase Transitions Associated with DNA Replication


Descriptive Note : Journal article


Corporate Author : BIOTECHNOLOGY HPC SOFTWARE APPLICATIONS INST FORT DETRICK MD


Personal Author(s) : Woo, Hyung-June ; Wallqvist, Anders


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a537012.pdf


Report Date : 11 Feb 2011


Pagination or Media Count : 5


Abstract : Thermodynamics governing the synthesis of DNA and RNA strands under a template is considered analytically and applied to the population dynamics of competing replicators. We find a nonequilibrium phase transition for high values of polymerase fidelity in a single replicator, where the two phases correspond to stationary states with higher elongation velocity and lower error rate than the other. At the critical point, the susceptibility linking velocity to thermodynamic force diverges. The overall behavior closely resembles the liquid-vapor phase transition in equilibrium. For a population of self-replicating macromolecules, Eigen's error catastrophe transition precedes this thermodynamic phase transition during starvation. For a given thermodynamic force, the fitness of replicators increases with increasing polymerase fidelity above a threshold.


Descriptors :   *RIBONUCLEIC ACIDS , *DEOXYRIBONUCLEIC ACIDS , *NONEQUILIBRIUM FLOW , PHASE TRANSFORMATIONS , THERMODYNAMICS , STRANDS , VAPOR PHASES , ELONGATION , DYNAMICS , SYNTHESIS , STARVATION , POLYMERIZATION


Subject Categories : Biochemistry


Distribution Statement : APPROVED FOR PUBLIC RELEASE