Accession Number : ADA536462


Title :   In Utero Exposure to Dietary Methyl Nutrients and Breast Cancer Risk in Offspring


Descriptive Note : Annual rept. 25 Aug 2009-24 Aug 2010


Corporate Author : NORTH DAKOTA STATE UNIV FARGO


Personal Author(s) : Park, Chung S


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a536462.pdf


Report Date : Sep 2010


Pagination or Media Count : 9


Abstract : Lipotropes (methionine, choline, folate, and vitamin B12) are dietary methyl donors and cofactors that are involved in one-carbon metabolism providing methyl groups for all biological methylation pathways. This study assessed the effect of maternal lipotrope supplementation on breast cancer risk of the offspring using chemically-induced mammary carcinogenesis. We hypothesize that lipotrope supplementation reduces breast cancer risk of the offspring by inducing an epigenetic imprint (memory) of the expression of genes involved in development and differentiation of mammary tissue. In a series of in vivo experiments, the latency period was significantly increased in offspring with maternal lipotrope supplementation (2.17 weeks, P=0.008). Moreover, maternal lipotrope diet significantly reduced tumor volume (P=0.007) and tumor number (P=0.001) in offspring. The results suggest that maternal dietary lipotrope may reduce breast cancer risk of offspring, and warrants further investigation for development of dietary strategies for breast cancer reduction.


Descriptors :   *BREAST CANCER , *DIET , *METABOLISM , *METHIONINE , *CHOLINES , *METHYL RADICALS , GENES , IN VIVO ANALYSIS , MAMMARY GLANDS , METHYLATION , FOLIC ACID , DONORS(MEDICINE) , NUTRIENTS , CARBON , NEOPLASMS , CHEMICALS , ONCOGENESIS , TISSUES(BIOLOGY) , RISK


Subject Categories : Biochemistry
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE