Accession Number : ADA536317


Title :   Dietary and Environmental Exposure to Cadmium and the Risk of Breast Cancer


Descriptive Note : Annual rept. 15 Sep 2009-14 Sep 2010


Corporate Author : CANCER PREVENTION INST OF CALIFORNIA FREMONT


Personal Author(s) : Rull, Rudolph


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a536317.pdf


Report Date : 01 Oct 2010


Pagination or Media Count : 25


Abstract : This proposed study will examine whether exposure to cadmium (Cd) from dietary or environmental sources increases the risk of breast cancer. We will examine this hypothesis using information collected from the California Teachers Study (CTS) cohort, a group of approximately 130,000 female school employees living in California followed for breast cancer since 1995. Information collected by questionnaire includes residential addresses, exposure to tobacco smoke, and food and beverage consumption. We will assess levels of dietary and environmental exposure by linking these collected data with available information on Cd residue levels in foods and beverages and environmental sources of Cd pollution near women's residences. In addition, we will estimate total Cd exposure by using existing urine samples provided by 304 women in the CTS to determine the relative contributions of dietary and environmental sources to the level of urinary Cd, which is considered a good measure of cumulative lifetime exposure. We will then evaluate whether dietary, environmental, and total exposure to Cd increase the risk of breast cancer. We made substantial progress in the second year of the study. We created the analytic datasets and completed the initial dietary and environmental exposure assessments. In addition, we identified predictors of urinary Cd concentrations among participants in the exposure validation sub-study. We are preparing our first manuscript and will initiate the breast cancer risk analyses.


Descriptors :   *CADMIUM , *EXPOSURE(PHYSIOLOGY) , *BREAST CANCER , TABLES(DATA) , DIET , URINE , LINEAR REGRESSION ANALYSIS , SAMPLING , RISK , ENVIRONMENTS


Subject Categories : Medicine and Medical Research
      Inorganic Chemistry


Distribution Statement : APPROVED FOR PUBLIC RELEASE