Accession Number : ADA535275


Title :   Genetically Modified Porcine Skin Grafts for Treatment of Severe Burn Injuries


Descriptive Note : Annual rept. 1 Jul 2009-30 Jun 2010


Corporate Author : MASSACHUSETTS GENERAL HOSPITAL BOSTON


Personal Author(s) : Sachs, David H ; Cetrulo, Jr, Curtis L


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a535275.pdf


Report Date : Jul 2010


Pagination or Media Count : 139


Abstract : The most significant research findings in this time period include the fact that we have demonstrated that our genetically-modified pigskin grafts will perform as well human cadaveric allogeneic skin grafts as a temporary biologic cover for severe burn injuries for war-fighters. Our xenoskin transplants from pig to baboons have confirmed that our genetically-modified pigskin grafts last as long as baboon allograft skin, are not damaged by freezing, and are effective at treating full-thickness skin injuries typically seen in burn injuries sustained in combat. In addition, a short course of immunosuppression may enhance the efficacy of these grafts. Finally, our in vitro analysis has suggested a number of immunologic targets that may improve this approach in particular and xenotransplantation in general.


Descriptors :   *SKIN GRAFTS , IMMUNOSUPPRESSION , EPIDERMIS , SURGICAL TRANSPLANTATION , SWINE , GENETIC ENGINEERING , BURNS(INJURIES)


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE