Accession Number : ADA529089


Title :   Peptides for Specific Intracellular Delivery and Targeting of Nanoparticles: Implications for Developing Nanoparticle-Mediated Drug Delivery


Descriptive Note : Journal article


Corporate Author : NAVAL RESEARCH LAB WASHINGTON DC CENTER FOR BIOMOLECULAR SCIENCE AND ENGINEERING


Personal Author(s) : Delehanty, James B ; Boeneman, Kelly ; Bradburne, Christopher E ; Robertson, Kelly ; Bongard, Jason E ; Medintz, Igor L


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a529089.pdf


Report Date : Jan 2010


Pagination or Media Count : 24


Abstract : The use of peptides to mediate the delivery and uptake of nanoparticle (NP) materials by mammalian cells has grown significantly over the past 10 years. This area of research has important implications for the development of new therapeutic materials and for the emerging field of NP-mediated drug delivery. In this review, we highlight recent advances in the delivery of various NPs by some of the more commonly employed cellular delivery peptides and discuss important related factors such as NP-peptide bioconjugation, uptake efficiency, intracellular fate and toxicity. We also highlight various demonstrations of therapeutic applications of NP-peptide conjugates where appropriate. The paper concludes with a brief forward-looking perspective discussing what can be expected as this field develops in the coming years.


Descriptors :   *DELIVERY , *DRUGS , *NANOPARTICLES , CELLS(BIOLOGY) , PEPTIDES , REPRINTS , THERAPY


Subject Categories : Biochemistry
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE