Accession Number : ADA527644


Title :   A Genome-Wide Breast Cancer Scan in African Americans


Descriptive Note : Annual rept. 1 Jun 2009-31 May 2010


Corporate Author : UNIVERSITY OF SOUTHERN CALIFORNIA LOS ANGELES


Personal Author(s) : Haiman, Christopher A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a527644.pdf


Report Date : 01 Jun 2010


Pagination or Media Count : 15


Abstract : This genome-wide association of breast cancer includes over 3,000 African American women with invasive disease and over 3,000 age-matched African American controls from many existing case-control studies of breast cancer in the U.S. In the first year of this project all DNA samples from these studies were sent to Dr. Haiman?s laboratory at the University of Southern California, quantitated and arrayed for genotyping. We have also assembled the covariate file that contains established breast cancer risk factor data collected from these studies, and the data have been standardized for the analysis. As of April 1, 2009, we have genome-wide scanned 2,200 cases and 2,200 controls from a number of the participating studies using the Illumina 1M Beadchip. We have assessed the blinded quality control replicates and overall call rates by SNP and sample and the data appear to be of very high quality. We have conducted a very preliminary statistical analysis of the data and there are a number of promising signals including what we believe is a novel risk locus for breast cancer that may be of particular importance for estrogen receptor negative breast cancer. The analysis will continue as additional samples/studies are scanned over the next year


Descriptors :   *BREAST CANCER , *AFRICAN AMERICANS , *ESTROGENS , *RECEPTOR SITES(PHYSIOLOGY) , *GENOME , QUALITY CONTROL , LABORATORIES , STATISTICAL ANALYSIS , SAMPLING , CASE STUDIES , DEOXYRIBONUCLEIC ACIDS , DISEASES , RISK , GENES


Subject Categories : Biochemistry
      Genetic Engineering and Molecular Biology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE