Accession Number : ADA527587


Title :   Descriptive Biomarkers for Assessing Breast Cancer Risk


Descriptive Note : Annual rept. 15 Sep 2008-14 Sep 2009


Corporate Author : MASSACHUSETTS UNIV AMHERST


Personal Author(s) : Arcaro, Kathleen F


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a527587.pdf


Report Date : Oct 2009


Pagination or Media Count : 18


Abstract : The purpose of this research is to determine if exfoliated epithelial cells present in breast milk can be used to assess a woman's individual risk of developing breast cancer and to detect early signs of breast cancer. To accomplish this goal we are collecting breast milk samples from 250 lactating women who either have had a breast biopsy or are scheduled for a breast biopsy. We are isolating the epithelial cells and determining the DNA promoter methylation patterns of several tumor-suppressor genes that are frequently methylated in breast cancer. During the first year we have been extremely successful with subject recruitment and sample collection and processing. We have completed Tasks 1 through 4 and have made significant progress on Tasks 5 and 6. We have not encountered any problems and remain on schedule.


Descriptors :   *CELLS(BIOLOGY) , *MILK , *BREAST CANCER , *EPITHELIUM , *LACTATES , *REPRODUCTION(PHYSIOLOGY) , SUPPRESSORS , TRACER STUDIES , METHYLATION , EXFOLIATION , BIOPSY , MAMMARY GLANDS , GENES , DEOXYRIBONUCLEIC ACIDS , NEOPLASMS , RECRUITING , RISK


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE