Accession Number : ADA526578


Title :   Role of Hsp90 in Androgen-Refractory Prostate Cancer


Descriptive Note : Final rept. 1 Mar 2007-28 Feb 2010


Corporate Author : PITTSBURGH UNIV PA


Personal Author(s) : Wang, Zhou


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a526578.pdf


Report Date : Mar 2010


Pagination or Media Count : 23


Abstract : A major challenge in prostate cancer research is to develop novel therapies that can delay or prevent the progression of androgen-sensitive prostate cancer to androgen-independence. Androgen receptor (AR) is often overexpressed and plays an essential role in androgen-refractory prostate tumors. Our preliminary studies suggest that heat shock protein 90 (Hsp90) is required for androgen-independent AR nuclear localization in androgen-refractory prostate cancer cells. This project tested our research hypothesis that Hsp90 plays a critical role in ligand-independent AR nuclear localization, an essential step leading to androgen-refractory prostate cancer. During the funding period, we showed that Hsp90 deacetylation by HDAC6 is a critical step involved in castration resistance of prostate cancer cells.


Descriptors :   *ANDROGENS , *PROSTATE CANCER , MEDICAL RESEARCH , PROTEINS , CELLS(BIOLOGY)


Subject Categories : Biochemistry
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE