FoxP3 as a Missing Link between Breast Cancer and Inflammation
Annual rept. 1 Sep 2008-31 Aug 2009
MICHIGAN UNIV ANN ARBOR
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This is the first annual report on the grant FoxP3 as a missing link between breast cancer and inflammation. Given the importance of both cancer-cell intrinsic cancer gene and extrinsic inflammation pathways, it is especially intriguing and appropriate to investigate the effect of genetic alteration in genes that have both cancer cell-intrinsic and extrinsic functions, as they may play a unique--and as yet unrecognized-- role in the pathogenesis of breast cancer. The FoxP3 gene is unique in this regard, in that its alteration can affect both cancer cell-intrinsic function and inflammation. Our proposed work will address the role for inflammation associated with adaptive and innate immune response in the pathogenesis of mammary cancer in female mice with a FoxP3 mutation. Despite a setback caused by an outbreak of mouse hepatitis virus that lead to termination of the mouse clonies specifically generated for the proposed studies, we made an important observation that targeted mutation of FoxP3 genes in the epithelial cells, resulted in expression of IL-1 alpha and IL1 beta, key regulators of inflammation. More importantly, expression of IL1b associated with strong inflammation.
- Anatomy and Physiology
- Medicine and Medical Research