Accession Number : ADA516471


Title :   The SDF-1-CXCR4 Axis Functions Through p38-MAPK Signaling to Drive Breast Cancer Progression and Metastasis


Descriptive Note : Annual summary 30 Aug 2008-29 Aug 2009


Corporate Author : TULANE UNIV NEW ORLEANS LA


Personal Author(s) : Vanhoy, Lyndsay


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a516471.pdf


Report Date : Sep 2009


Pagination or Media Count : 26


Abstract : The primary long-term objective of this research is to understand how chemokine signaling through MAPK influences progression of breast carcinoma cells to a hormone-independent, endocrine therapy resistant and metastatic phenotype. Our preliminary evidence demonstrates that over expression of CXCR4 in breast carcinoma cells leads to a hormone independent phenotype in vivo. It was also determined by our lab that human mesenchymal stem cells in contact with breast cancer cells (MCF7 cell line) could induce proliferation and lead to hormone independent tumors in vivo. Upon analysis of these tumors by real-time PCR, it was found that the MSC containing tumors had increased gene transcription of progesterone receptor as well as SDF-1 indicating ER crosstalk. Future studies are planned to look more closely at the mechanisms involved in this MSC- tumor cell interaction, specifically identifying a role for SDF-1. We propose SDF-1 is the primary factor involved, either being secreted by the MSCs or the MSCs are stimulating its production in the carcinoma cells themselves. Future plans involve using MSCs as source for SDF-1 to test previously outlined objectives.


Descriptors :   *BREAST CANCER , *METASTASIS , INTERACTIONS , NEOPLASMS , DRIVES , EMBRYOS , CELLS(BIOLOGY) , CROSSTALK , SENSE ORGANS , CANCER , MAMMARY GLANDS , CONNECTIVE TISSUE , PROGESTERONE , STEM CELLS , REAL TIME , HUMANS


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE