Accession Number : ADA515431


Title :   Biocompatible and Biomimetic Self-Assembly of Functional Nanostructures


Descriptive Note : Final rept. Dec 2006-Nov 2009


Corporate Author : NEW MEXICO UNIV REGENTS ALBUQUERQUE


Personal Author(s) : Brinker, C J ; Carnes, Eric C


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a515431.pdf


Report Date : 28 Feb 2010


Pagination or Media Count : 46


Abstract : We have discovered and continue to explore a unique metabolically and optically controlled lithography approach that allows patterned integration of live cells into nominally solid-state devices and maintains their viability under extreme conditions of desiccation and starvation. We used our cellular integration approach to explore quorum sensing at the individual cell level. We have also developed techniques for the integration of mammalian cells into devices. We continue to create biocompatible cellular microenvironments with tailored chemical and physical properties that direct cellular behavior. In summary our research provides a means to integrate cells into devices and platforms, maintain their viability under harsh conditions, and direct their behavior thorough engineered microenvironments.


Descriptors :   *NANOSTRUCTURES , *BIOMIMETICS , *SOLID STATE ELECTRONICS , *SELF ASSEMBLED MONOLAYERS , ENGINEERING , INTEGRATION , BIOTECHNOLOGY , NANOTECHNOLOGY , SOL GEL PROCESSES , LITHOGRAPHY , PHYSICAL PROPERTIES , CHEMICAL PROPERTIES , STARVATION , VIABILITY


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research
      Electrical and Electronic Equipment
      Bionics


Distribution Statement : APPROVED FOR PUBLIC RELEASE