Accession Number : ADA513184


Title :   Department of Defense Era of Hope Scholar Award Nanotechnology-Enabled Optical Molecular Imaging of Breast Cancer


Descriptive Note : Annual rept. 15 Jun 2008-14 Jun 2009


Corporate Author : RICE UNIV HOUSTON TX


Personal Author(s) : Drezek, Rebekah


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a513184.pdf


Report Date : 01 Jul 2009


Pagination or Media Count : 105


Abstract : This project focuses on development of nanotechnology-enabled optical molecular imaging technologies for applications in both breast cancer diagnosis and monitoring therapeutic response. The project consists of two major efforts: (1) optical instrumentation technology development and (2) development of complementary engineered nanomaterials for use in conjunction with the instrumentation created to provide molecular specificity. A particularly significant effort is underway to develop needle-compatible fiber optic probes to enable in vivo imaging of tumors with micron resolution in order to provide a new microscopic, high resolution imaging modality to complement the low resolution, macroscopic imaging modalities already in common clinical use. Over the first two years of this effort, a first and second generation needle-compatible fiber optic probe system have been developed as have new methods for synthesis and bioconjugation of shaped and layered gold nanoparticle imaging agents and cadmium-free luminescent quantum dots.


Descriptors :   *DIAGNOSIS(MEDICINE) , *OPTICAL INSTRUMENTS , *BREAST CANCER , *CLINICAL MEDICINE , LOW RESOLUTION , HIGH RESOLUTION , AWARDS , IMAGES , OPTICS , IN VIVO ANALYSIS , SYNTHESIS(CHEMISTRY) , MONITORING , DEPARTMENT OF DEFENSE , RESPONSE(BIOLOGY)


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE