Accession Number : ADA512945


Title :   Novel Strategies for the Treatment of Estrogen Receptor-Negative Breast Cancer


Descriptive Note : Annual summary rept. 4 Sep 2006-3 Mar 2009


Corporate Author : BAYLOR COLL OF MEDICINE HOUSTON TX


Personal Author(s) : Speers, Corey


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a512945.pdf


Report Date : Apr 2009


Pagination or Media Count : 300


Abstract : Previous gene expression profiling studies of breast cancer have focused on the entire genome to identify genes differentially expressed between estrogen receptor (ER)-positive and ER-negative cancers. Here we report a distinct kinase gene expression profile that identifies ER-negative breast tumors and subsets ER-negative breast tumors into 4 distinct subtypes. Furthermore, we show that this specific kinase profile is validated in breast cancer cell lines and independent sets of human tumors. Kinase expression knock-down studies show that many of these kinases are essential for the growth of ER-negative, but not ER-positive, breast cancer cell lines. Finally, survival analysis of patients with breast cancer shows that the S6 kinase pathway signature of ER-negative cancer confers an extremely poor prognosis, while patients whose tumors express high levels of immunomodulatory kinases have a significantly better prognosis. This study identifies a list of kinases that are prognostic and may serve as druggable targets for the treatment of ER-negative breast cancer.


Descriptors :   *RECEPTOR SITES(PHYSIOLOGY) , *BREAST CANCER , *PHOSPHORUS TRANSFERASES , *ESTROGENS , GENOME , CELLS(BIOLOGY) , GENES , NEOPLASMS


Subject Categories : Genetic Engineering and Molecular Biology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE