Accession Number : ADA512941


Title :   Molecular Genetic and Gene Therapy Studies of the Musculoskeletal System


Descriptive Note : Final rept. 9 Sep 2003-31 Aug 2009


Corporate Author : LOMA LINDA VETERANS ASSOCIATION FOR RESEARCH AND EDUCATION REDLANDS CA


Personal Author(s) : Mohan, Subburaman


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a512941.pdf


Report Date : Sep 2009


Pagination or Media Count : 547


Abstract : The proposed research projects focuses on bone health, including relevance to the musculoskeletal system in battlefield performance and in battlefield injury. We have utilized state-of-the-art molecular genetic and gene therapy technologies to address fundamental questions in bone biology with particularly emphasis on attempting to clarify gene function for those genes that are involved in digit tip regeneration, bone size, skeletal repair and anabolic response to mechanical loading. The molecular genetic approaches have utilized various knockout mouse models and whole genome microarray analysis for evaluation of gene functions. The gene therapy approaches have utilized various viral and non-viral vectors to transfer gene of interest to treat localized and systemic skeletal deficits. We have successfully accomplished nearly all of the objectives proposed in the grant. The four core facilities funded by this project have contributed enormously to the success of our research activities. Our research activities during the past funding period have lead to 14 publications and 14 abstracts. Our studies have led to the identification of key genes and their pathways that are involved in skeletal regeneration and repair. Furthermore, we have developed successful gene therapy application to promote healing of skeletal injuries and increase bone formation throughout the skeleton.


Descriptors :   *MUSCULOSKELETAL SYSTEM , *GENE THERAPY , *GENETICS , *MOLECULAR BIOLOGY , STRAIN(MECHANICS) , BLAST , BONES , OSTEOLYSIS , ARRAYS , PATHS , BATTLEFIELDS , QUANTITATIVE ANALYSIS , WOUNDS AND INJURIES


Subject Categories : Genetic Engineering and Molecular Biology
      Anatomy and Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE