Accession Number : ADA509469


Title :   A Review on Pharmacokinetic Modeling and the Effects of Environmental Stressors on Pharmacokinetics for Operational Medicine: Operational Pharmacokinetics


Descriptive Note : Technical rept.


Corporate Author : DEFENCE RESEARCH AND DEVELOPMENT TORONTO (CANADA)


Personal Author(s) : Peng, Henry ; Cheung, Bob


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a509469.pdf


Report Date : Sep 2009


Pagination or Media Count : 125


Abstract : In this report, we conducted a comprehensive literature review on the effects of a range of physiological and psychological stressors on drug absorption, distribution and elimination (pharmacokinetics), and current pharmacokinetic models (including computerized modeling tools and algorithms) used to predict pharmacokinetic changes. Although sophisticated computerized mathematical models have been widely used to quantitatively describe the pharmacokinetics of drugs in the human body, limited experimental data for both descriptive and predictive purposes were available. The effects of isolated physical activities on pharmacokinetics have been documented. However, some inconsistencies need to be addressed, such as the intensity and duration of each physical activity, and timing of drug administration. Other physiological stressors, such as temperature, hypoxic, hyperbaric and hyperoxic conditions have been studied to a lesser extent. There are only a few reports describing the psychological effects on drug pharmacokinetics. After carefully reviewing the literature, our goal is to develop a physiologically-based pharmacokinetic model to predict the absorption, distribution and elimination of drugs employed under various military physiological and psychological stressors.


Descriptors :   *PHARMACOKINETICS , ALGORITHMS , COMPUTERIZED SIMULATION , MILITARY OPERATIONS , ENVIRONMENTS , DRUGS , MODELS , CANADA , DOSAGE , ABSORPTION , MATHEMATICAL MODELS , MILITARY FORCES(FOREIGN)


Subject Categories : Pharmacology
      Military Operations, Strategy and Tactics


Distribution Statement : APPROVED FOR PUBLIC RELEASE