Accession Number : ADA505338


Title :   Detection and Evaluation of Early Breast Cancer via Magnetic Resonance Imaging: Studies of Mouse Models and Clinical Implementation


Descriptive Note : Annual summary rept. 6 Feb 2006-5 Feb 2009


Corporate Author : CHICAGO UNIV IL


Personal Author(s) : Jansen, Sanaz A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a505338.pdf


Report Date : Mar 2009


Pagination or Media Count : 199


Abstract : The early detection of breast cancer is a major prognostic factor in the management of the disease. In particular, detecting breast cancer in its pre-invasive form as ductal carcinoma in situ (DCIS) improves prognosis greatly compared with invasive tumors. Although dynamic contrast enhanced MR imaging (DCEMRI) of the breast has demonstrated high sensitivity to invasive breast cancer, there is room for improving the diagnostic accuracy of DCEMRI to DCIS. However, a competing clinical concern is that DCIS is being overdiagnosed and overtreated, as there is evidence to suggest that not all DCIS lesions will progress into invasive cancers. Ideally, improvements in the detection of DCIS would be accompanied by an improved understanding of its natural history?which lesions will progress to invasive cancer, and which will not? The goals of this proposal are to improve sensitivity and specificity of DCEMRI to DCIS by comparing its kinetic and morphologic features with other types of breast lesions, and to use mouse models to probe the progression of DCIS into invasive cancer. Specifically, we have (i) characterized the MR kinetic and morphologic findings of DCIS in women and compared with benign lesions and other malignant cancers, (ii) developed techniques to detect early mammary cancer in mice, and (iii) studied the development and progression of early mammary cancer in mice by performing longitudinal MRI studies of development of DCIS and transition to invasive cancer. We have developed a novel approach to investigating the natural history of breast cancer by using high resolution MR imaging to image early murine mammary cancer and study the transition from in situ to invasive disease in vivo.


Descriptors :   *BREAST CANCER , *DIAGNOSIS(MEDICINE) , *MAGNETIC RESONANCE IMAGING , NEOPLASMS , HIGH RESOLUTION , IN VIVO ANALYSIS , WOMEN , NATURAL HISTORY , LESIONS , MAMMARY GLANDS , HIGH SENSITIVITY , MORPHOLOGY , PREDICTIONS , CONTRAST , DETECTION


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE