Accession Number : ADA504964


Title :   Enhancing Quality of Life for Breast Cancer Patients with Bone Metastases


Descriptive Note : Annual summary rept. 15 Mar 2007-14 Mar 2008


Corporate Author : SYRACUSE UNIV RESEARCH FOUNDATION NY


Personal Author(s) : Arrington, Sarah A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a504964.pdf


Report Date : Apr 2008


Pagination or Media Count : 47


Abstract : Current treatment for osteolytic breast cancer bone metastasis typically involves radiation therapy (RTX) to palliate bone pain and a bisphosphonate to inhibit osteoclastic bone resorption. The goal of this research was to determine the effects of zoledronic acid as an adjunct to RTX on restoring bone strength and density. We also investigated whether the combination of ZA and an anabolic agent (parathyroid hormone, PTH) as adjuncts to RTX further enhanced bone strength and thus decrease the risk of subsequent pathological fractures.


Descriptors :   *BONES , *BREAST CANCER , DOSE RATE , METASTASIS , RADIOTHERAPY , PATIENTS , DENSITY , HISTOLOGY


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE