Accession Number : ADA503186


Title :   Antingens for a Vaccine that Prevents Severe Malaria


Descriptive Note : Final rept. 1 Feb 2005-31 Jan 2009


Corporate Author : SEATTLE BIOMEDICAL RESEARCH INST WA


Personal Author(s) : Duffy, Patrick E


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a503186.pdf


Report Date : 01 Mar 2009


Pagination or Media Count : 50


Abstract : Malaria is the primary infectious disease threat facing the U.S. soldier, and is the leading cause of all causalities during tropical deployments. The long-term objective of this project is to identify and prepare the malaria parasite forms causing severe anemia, and then apply functional genomics and bioformatics tools to identify 15 to 30 proteins that could form the basis for an effective vaccine at both the pre-erythrocytic and blood stages of malaria infection. The project will then evaluate these lead candidates for their recognition by sera collected from immune individuals, in order to identify the leading 3 to 5 candidates for a blood stage vaccine that prevents severe malaria anemia.


Descriptors :   *INFECTIOUS DISEASES , *PREVENTIVE MEDICINE , *VACCINES , *PLASMODIUM FALCIPARUM , *MALARIA , ANEMIAS , ANTIGENS , TROPICAL REGIONS , ARMY PERSONNEL , THREATS


Subject Categories : Medicine and Medical Research
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE