Accession Number : ADA502828


Title :   Effects of Radiation on Proteasome Function in Prostate Cancer Cells


Descriptive Note : Annual summary rept. 15 Jan 2008-14 Jan 2009


Corporate Author : CALIFORNIA UNIV LOS ANGELES


Personal Author(s) : Pajonk, Frank


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a502828.pdf


Report Date : 01 Feb 2009


Pagination or Media Count : 25


Abstract : The proposed research is based on our observation that the 26S proteasome is a direct target of radiation. We initially planned experiments to investigate the association and release of PIPs from the 26S proteasome as well as studies more focused on the structural changes of the proteasome in response to radiation. We also wanted to investigate how the 26S is regulated by radiation at the transcriptional and posttranslational level and we are addressing these aims using powerful proteomic tools.


Descriptors :   *CELLS(BIOLOGY) , *PROSTATE CANCER , RADIATION , STRUCTURAL PROPERTIES


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research
      Radiobiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE