Accession Number : ADA502764


Title :   Bacteroides Fragilis OmpA: Utility as a Live Vaccine Vector for Biodefense Agents


Descriptive Note : Final rept. 30 Dec 2004-29 Dec 2008


Corporate Author : BRENTWOOD BIOMEDICAL RESEARCH INST LOS ANGELES CA


Personal Author(s) : Wexler, Hannah M


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a502764.pdf


Report Date : Jan 2009


Pagination or Media Count : 75


Abstract : This study was designed to address a vital concern to our national security: the danger of infectious agents being used vehicles of bioterror. Means to both prevent infection with these agents and to treat infections that may occur are being studied with intensity. Historically, vaccines have been the most efficient method of preventing diseases in large populations, and certainly, in the last decade or so we have seen a precipitous rise in the percentages of multiantimicrobial resistant bacteria. Over the past 15 years, scientists have developed experimental bacterial vaccine vectors that elicit immune responses against bacterial, viral, protozoan and metazoan pathogens in laboratory animals 28. Among the advantages of these vaccines is that they are relatively inexpensive to manufacture, they can be given orally, and they can be treated with antibiotics if desired. Ideally, the delivery vector should be able to be manipulated to present the antigen optimally. Several organisms have been used in these systems 28 and results suggest that this method is very promising for antigens from both viral and bacterial pathogens to elicit mucosal IgA and T cell responses.


Descriptors :   *BACTEROIDES , *BIOLOGICAL AGENTS , *LIVE VACCINES , INFECTIOUS DISEASES , ANTIGENS , PATHOGENIC MICROORGANISMS , DISEASE VECTORS , RESPONSE(BIOLOGY) , POPULATION , NATIONAL SECURITY , T LYMPHOCYTES


Subject Categories : Medicine and Medical Research
      Microbiology
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE