Accession Number : ADA502025


Title :   Efficacy of the Tertiary Oxime Monoisonitrosoacetone (MINA) Against Lethal Sarin Intoxication in the Guinea Pig


Descriptive Note : Technical rept. Sep 2006-Oct 2006


Corporate Author : ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD


Personal Author(s) : Koplovitz, Irwin ; Schulz, Susan M


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a502025.pdf


Report Date : Oct 2007


Pagination or Media Count : 13


Abstract : A major limitation of currently available oximes is their inability to readily cross the blood brain barrier and reactivate acetylcholinesterase (AChE) that has been inhibited by nerve agents. MINA is a tertiary oxime that readily enters the brain and was reported more than 50 years ago to be effective against lethal nerve agent intoxication. The purpose of this preliminary study was to re-evaluate the efficacy of MINA as a treatment for lethal sarin (GB) intoxication in guinea pigs. Male animals were challenged subcutaneously (s.c.) with 2 LD50s of GB and treated 1 min later with MINA, 2PAM, atropine, or diazepam alone or in various combinations. A total of 14 different treatment groups were evaluated, 7 with MINA and 7 without MINA. Survival was assessed 24 hr after GB challenge. All 69 (100%) animals treated with MINA survived, whereas only 26 of 70 (37%) animals without MINA survived. The results clearly demonstrate the effectiveness of MINA and the potential benefit of using oximes that are readily able to enter the brain.


Descriptors :   *LETHAL AGENTS , *INTOXICATION , *OXIMES , *GUINEA PIGS , *GB AGENT , BLOOD BRAIN BARRIER , DIAZEPAM , NERVE AGENTS , ACETYLCHOLINESTERASE , LETHALITY , SURVIVAL(GENERAL) , BRAIN , ATROPINE


Subject Categories : Biochemistry
      Toxicology
      Chemical, Biological and Radiological Warfare


Distribution Statement : APPROVED FOR PUBLIC RELEASE