Accession Number : ADA501105


Title :   The Impact of Exercise on the Vulnerability of Dopamine Neurons to Cell Death in Animal Models of Parkinson's Disease


Descriptive Note : Final rept. 16 Jun 2003-15 Jun 2008


Corporate Author : PITTSBURGH UNIV PA


Personal Author(s) : Zigmond, Michael J ; Smith, Amanda ; Liou, Anthony


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a501105.pdf


Report Date : Jul 2008


Pagination or Media Count : 80


Abstract : Parkinson's disease results in part from the loss of dopamine neurons. We hypothesize that exercise reduces the vulnerability of dopamine neurons to neurotoxin exposure, which is modulated by stress. We have outlined experiments to test this hypothesis in rats treated with one of several neurotoxins, beginning with 6-hydroxydopamine. Over the past year, we increased the size and training of our research team and made a number of observations of direct relevance to our hypothesis. We also have received permission to expand our original Statement of Work to include critical studies on the mechanism of the actions of exercise, using both in vivo and in vitro approaches. Our focus continues to be on the effects of stress and exercise on the vulnerability of DA neurons, and the role played in these phenomena by trophic factors and intracellular signaling cascades.


Descriptors :   *PARKINSONS DISEASE , VULNERABILITY , NERVE CELLS , ANIMALS , DOPAMINE , CNS DEPRESSANTS , EXERCISE(PHYSIOLOGY) , NEUROTOXINS , MODELS , CELLS(BIOLOGY)


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE