Accession Number : ADA500671


Title :   Control of Growth Within Drosophila Peripheral Nerves by Ras and Protein Kinase A


Descriptive Note : Final rept. 27 Jan 2004-26 Jan 2009


Corporate Author : RICE UNIV HOUSTON TX


Personal Author(s) : Stern, Michael


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a500671.pdf


Report Date : Feb 2009


Pagination or Media Count : 48


Abstract : The long term goals of this research are to understand the mechanisms by which NF1 and its partners control growth using the Drosophila peripheral nerve as our assay system. This system is advantageous because we can apply a number of powerful molecular genetic methodologies that are not available in other systems. Our major findings were generated from aim #4. We reported after year2 that Ras nonautonomously activates perineurial glial growth via PI3 Kinase, Akt and FOXO (published in the Journal of Neuroscience in 2007). Second, we report preliminary evidence that pushover (push) acts in the glia to regulate perineurial glial growth, but in the neuron to regulate excitability. Third, we report that activation of the Tor pathway is necessary but not sufficient to increase perineurial glial growth. Fourth, we report that the metabotropicglutamate receptor regulates neuronal growth and excitability via PI3K.


Descriptors :   *GENETICS , *GROWTH(PHYSIOLOGY) , *PERIPHERAL NERVOUS SYSTEM , *NERVE CELLS , DROSOPHILA , PHOSPHORUS TRANSFERASES , PROTEINS , MOLECULES , CONTROL


Subject Categories : Genetic Engineering and Molecular Biology
      Anatomy and Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE