Accession Number : ADA499607


Title :   The Function of PTP1B in Neuroendocrine Differentation of Prostate Cancer


Descriptive Note : Annual rept. 1 Jan -31 Dec 2008


Corporate Author : ROCHESTER UNIV NY


Personal Author(s) : Huang, Jiaoti


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a499607.pdf


Report Date : Jan 2009


Pagination or Media Count : 37


Abstract : The goal of the project is to identify the molecular mechanisms responsible for therapeutic failure in prostate cancer patients receiving hormonal therapy Scope: The scope of the project is to use prostate cancer cell lines in in-vitro cell culture systems to study the complex signal transduction pathways that may be responsible for the neuroendocrine differentiation of prostate cancer cells, particularly the relationship of PTP1B to IL-8 signaling through its receptors CXCR1 and CXCR2, to IGF- 1 receptor signaling through PI3 kinase/AKT/mTOR pathway and to androgen receptor signaling. Major findings: 1. We have shown that IGF-1 receptor may be a critical player in androgen-withdrawal-induced neuroendocrine differentiation of prostate cancer cell line LNCaP. 2. We have shown that IGF-1 receptor is activated by the expression of a protein tyrosine phosphatase PTP1B in LNCaP cells, which may be responsible for the activation of AKT signaling pathway. In addition, our results suggest that this activity of PTP1B appears to be independent of its tyrosine phosphatase enzymatic activity.


Descriptors :   *CELLS(BIOLOGY) , *ANDROGENS , *PROSTATE CANCER , IN VITRO ANALYSIS , THERAPY , TRANSDUCERS , PATIENTS , PHOSPHATASES , ACTIVATION , CULTURES(BIOLOGY) , SENSE ORGANS , TYROSINE , ENZYMES , HORMONES , MOLECULAR PROPERTIES


Subject Categories : Biochemistry
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE