Accession Number : ADA492892


Title :   Castration Induced Neuroendocrine Mediated Progression of Prostate Cancer


Descriptive Note : Final Addendum 1 Sep 2007-31 Aug 2008


Corporate Author : CALIFORNIA UNIV DAVIS


Personal Author(s) : Evans, Christopher P


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a492892.pdf


Report Date : Sep 2008


Pagination or Media Count : 107


Abstract : We explored the relationship between androgen withdrawal as an event that initiates a cascade promoting the development of androgen-independent prostate cancer through neuroendocrine progression. We define the early post-castration molecular events and linked androgen-deprivation therapy to the activation of non-receptor tyrosine kinases that promote androgen-independent growth and migration. We developed an animal model to validate this hypothesis that metastasize in SCID mice. We found that deregulation through non-receptor tyrosine kinases was blocked by Src-specific inhibitor AZD0530. We found this inhibited 100% of metastasis in an animal model. The translational benefit of this study was that through a National Cancer Institute sponsored trial, the drug is being tested for hormone refractory prostate cancer.


Descriptors :   *B LYMPHOCYTES , *PROSTATE CANCER , *METASTASIS , *T LYMPHOCYTES , TRANSCRIPTION(GENETICS) , RESPONSE(BIOLOGY) , MUTATIONS , MODELS , CHEMOTHERAPY


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE