Accession Number : ADA492663


Title :   Caffeine, Adenosine Receptors and Estrogen in Toxin Models of Parkinson's Disease


Descriptive Note : Annual rept. 1 Oct 2007-30 Sep 2008


Corporate Author : MASSACHUSETTS GENERAL HOSPITAL BOSTON


Personal Author(s) : Schwarzschild, Michael A ; Xu, Kui


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a492663.pdf


Report Date : 30 Oct 2008


Pagination or Media Count : 37


Abstract : Continued progress has been made toward each of the Specific Aims (SAs) 1 and 2 (SA 3 completed) of our research project, Caffeine, adenosine receptors and estrogen in toxin models of Parkinson's disease (PD) . The overarching hypothesis of the project is that multiple environmental protectants and toxins interact to influence of the health of the dopaminergic neurons lost in PD. To that end we are characterizing the interplay between several environmental agents (pesticides, caffeine and estrogen) that are leading candidate modulators of PD risk. In Year 4 we have obtained and reported evidence that the adenosine receptor blocker caffeine as well as specific genetic depletion of the A2A subtype of adenosine receptor are capable of conferring neuroprotection in chronic pesticide and genetic mouse models of PD. Critical to our ability to successfully pursue the Specific Aims of our research program, we have made technical progress in assessing modification of a key conditional KO methodology developed in this project. We have presented initial data applying this method to the MPTP model of neurodegeneration in PD.


Descriptors :   *ESTROGENS , *ADENOSINE , *PARKINSONS DISEASE , *CAFFEINE , AGING(PHYSIOLOGY) , PROTECTION , NERVE CELLS , MICE , MODULATORS , GENETICS , DOPAMINE , SENSE ORGANS , TOXINS AND ANTITOXINS , RECEPTOR SITES(PHYSIOLOGY) , PESTICIDES , MOTOR NEURONS , HEALTH , MODELS , RISK , DEPLETION , ENVIRONMENTS


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research
      Food, Food Service and Nutrition


Distribution Statement : APPROVED FOR PUBLIC RELEASE