Accession Number : ADA491731


Title :   Universal Breast Cancer Antigens as Targets Linking Early Detection and Therapeutic Vaccination


Descriptive Note : Annual summary rept. 11 Aug 2003-10 Aug 2008


Corporate Author : PENNSYLVANIA UNIV PHILADELPHIA


Personal Author(s) : Domchek, Susan M


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a491731.pdf


Report Date : Sep 2008


Pagination or Media Count : 19


Abstract : Molecular targets to facilitate early detection and preventative therapy for women at high risk for breast cancer have not been characterized. Two recently characterized intracellular enzymes human telomerase reverse transcriptase (hTERT) and the cytochrome P450 isoform 1B1 (CYP1B1), each overexpressed in 90% of invasive breast cancers but rarely found in normal tissue -- may fill this gap. Such targets, if found at the earliest time of malignant transformation, may be ideally suited not only for early detection but also cancer prevention by vaccination. A growing clinical experience in advanced cancer patients has underscored the safety and feasibility of vaccination strategies. The universal expression of hTERT and CYP1B1 provide an opportunity for both early detection and cancer vaccination. Objective/Hypothesis: We hypothesize that immunologic responses can be elicited in advanced breast cancer patients using vaccines incorporating hTERT, providing a safety and feasibility platform for ultimately vaccinating women at high risk for breast cancer. Although we have not found ductal lavage a feasible strategy for the detection of tumor antigens, we have made significant progress on vaccination strategies in women with metastatic breast cancer.


Descriptors :   *BREAST CANCER , *ANTIGENS , *IMMUNOTHERAPY , CELLS(BIOLOGY) , VACCINES , RETROVIRUSES , METASTASIS , FEASIBILITY STUDIES , CLINICAL MEDICINE , TISSUES(BIOLOGY) , IMMUNIZATION


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE