Accession Number : ADA491583


Title :   Estrogen-Induced Depurination of DNA: A Novel Target for Breast Cancer Prevention


Descriptive Note : Final rept. 7 Apr 2006-6 Apr 2007


Corporate Author : NEBRASKA UNIV MEDICAL CENTER OMAHA


Personal Author(s) : Cavalieri, Ercole L


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a491583.pdf


Report Date : May 2008


Pagination or Media Count : 94


Abstract : The research conducted in this COE grant is based on the paradigm that estrogens can become endogenous carcinogens when their metabolism is unbalanced, favoring formation of catechol estrogen quinones and their reaction with DNA. Compelling evidence obtained in the various specific aims of this COE will be decisive for determining the risk of breast cancer by using the depurinating estrogen-DNA adducts as biomarkers. These biomarkers will also be used for evaluating the ability of specific antioxidants to prevent breast cancer initiation. Much of the research accomplished by this COE was published in a review article in BBA-Reviews in Cancer, which was co-authored by all the participants of the COE.


Descriptors :   *RECEPTOR SITES(PHYSIOLOGY) , *ESTROGENS , *PREVENTIVE MEDICINE , *BREAST CANCER , *DEOXYRIBONUCLEIC ACIDS , TRACER STUDIES , ANTIOXIDANTS , CATECHOLAMINES , QUINONES , METABOLISM


Subject Categories : Biochemistry
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE