Accession Number : ADA490497


Title :   Determination of the Role of Estrogen Receptors and Estrogen Regulated Genes in B Cell Autoreactivity


Descriptive Note : Annual rept. 1 Jul 2007-30 Jun 2008


Corporate Author : FEINSTEIN INST FOR MEDICAL RESEARCH MANHASSET NY


Personal Author(s) : Diamond, Betty


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a490497.pdf


Report Date : Jul 2008


Pagination or Media Count : 14


Abstract : Systemic lupus erythematosus (SLE) is an autoimmune disease that occurs preferentially in women. In murine models of SLE it is clear that increased or sustained high physiologic levels of estradiol can accelerate onset of disease and exacerbate disease severity. We have shown that estradiol alters B cell maturation in vivo but does so in a genetically restricted fashion. We have also shown that estradiol can act directly on B cells to alter B cell receptor (BCR) signalling strength. This proposal is to understand which estrogen receptors mediate the effects of estradiol on B cell survival maturation and activation in order to assess whether hormonal manipulation has a potential therapeutic role in SLE. The proposal is further designed to ask why estradiol affects B cell function in mice of one genetic background but not another.


Descriptors :   *CELLS(BIOLOGY) , *ESTROGENS , *AUTOIMMUNE DISEASES , *LUPUS ERYTHEMATOSUS , *GENES , MATURATION , PHYSIOLOGY , MICE , B LYMPHOCYTES , WOMEN , ACTIVATION , RECEPTOR SITES(PHYSIOLOGY) , THERAPY , MODELS , SURVIVABILITY , HORMONES , GENETICS


Subject Categories : Genetic Engineering and Molecular Biology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE