Accession Number : ADA489763


Title :   In Silico Genome Mismatch Scanning to Map Breast Cancer Genes in Extended Pedigrees


Descriptive Note : Annual rept. 15 Jun 2007-14 Jun 2008


Corporate Author : UTAH UNIV SALT LAKE CITY


Personal Author(s) : Thomas, Alun


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a489763.pdf


Report Date : 01 Jul 2008


Pagination or Media Count : 56


Abstract : This project aims to map breast cancer genes using dense single nucleotide polymorphism arrays in large extended pedigrees. Data has been collected using a 1,000,000 SNP genotype assay for 25 women affected by breast cancer in three high risk Utah pedigrees. Preliminary analysis of control data has been performed and significant progress has been made on the problem of modeling linkage disequilibrium between genetic loci at the density and scale required by this project. Programs to perform the modeling and analysis have been written and tested. Two papers describing the methodological developments have been published and a third describing initial analyses of control data is in preparation. The project is proceeding as planned and we expect to carry out the remainder in good time.


Descriptors :   *GENETICS , *BREAST CANCER , *GENOME , *GENES , NUCLEOTIDES , HIGH DENSITY , ARRAYS


Subject Categories : Genetic Engineering and Molecular Biology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE