Accession Number : ADA489674


Title :   Targeting Therapy Resistant Tumor Vessels


Descriptive Note : Final rept. 1 may 2006-31 Aug 2008


Corporate Author : BURNHAM INST LA JOLLA CA


Personal Author(s) : Ruoslahti, Erkki


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a489674.pdf


Report Date : Aug 2008


Pagination or Media Count : 106


Abstract : Anti-angiogenic therapy appears to eliminate immature blood vessels. This paradoxically leads to improvement of tumor blood supply, as the structure and function of mature tumor blood vessels, not specific for anti-angiogenic effect, is normalized. This is a serious limitation to the anti-angiogenic therapy. The goal of this project is to specifically distinguish these normalized therapy resistant vessels in breast cancer from those sensitive to anti-angiogenic treatment. To achieve this, we have developed tumor models for vascular normalization and are using in vivo phage display and isolation of peptides that specifically home to normalized tumor vessels resistant to anti-angiogenic therapy. The results obtained in this study will enable specific targeting and thus treatment of breast cancer vessels not responding to standard anti-angiogenic therapy.


Descriptors :   *BREAST CANCER , *BLOOD VESSELS , NEOPLASMS , ANGIOGENESIS , RESISTANCE , PEPTIDES , THERAPY


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE