Accession Number : ADA486167


Title :   The Role of ABC Proteins in Drug Resistant Breast Cancer Cells


Descriptive Note : Annual summary rept. 15 Mar 2006-14 Mar 2008


Corporate Author : GEORGETOWN UNIV WASHINGTON DC


Personal Author(s) : Lekostaj, Jacqueline K


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a486167.pdf


Report Date : Apr 2008


Pagination or Media Count : 34


Abstract : This predoctoral training grant, supported by the Department of Defense Breast Cancer Research Program (BCRP) of the Office of the Congressionally Directed Medical Research Programs (CDMRP), aims to study the possible role of ABC transporters in pleitropic drug resistance, using a combination of molecular biological, biochemical, and biophysical methods. The second year of funding was spent working with a member of a drug/metabolite transporter superfamily called the Plasmodium falciparum Chloroquine Transporter (PfCRT). While PfCRT is known to be the main molecular determinant of chloroquine resistance, there is only indirect proof of its interaction with the drug. Therefore, I have employed a methodology commonly applied to drug resistance proteins (such as human P-glycoprotein) and labeled PfCRT with a photoaffinity drug analogue. A manuscript is currently in preparation detailing my results.


Descriptors :   *BREAST CANCER , *PROTEINS , DRUG TOLERANCE , RESISTANCE(BIOLOGY) , PLASMODIUM FALCIPARUM , CELLS(BIOLOGY)


Subject Categories : Biochemistry
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE