Accession Number : ADA485345


Title :   Endocrine Disruption and Human Prostate Cancer


Descriptive Note : Final rept. 1 Mar 2007-28 Feb 2008


Corporate Author : MONASH UNIV CLAYTON (AUSTRALIA)


Personal Author(s) : Risbridger, Gail


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a485345.pdf


Report Date : Mar 2008


Pagination or Media Count : 66


Abstract : Endocrine disrupting chemicals (EDCs) are present in our everyday life and many of them act to oppose androgens including the fungicide, Vinclozolin. Most of the studies on EDCs are conducted in rodents and have limited utility when extrapolating the findings to humans. In order to test the concept that Vinclozolin alters human prostate development and induces disease, we used our model system to study human prostate development and maturation over 8-12 weeks, comparable to the process that takes decades in men. Briefly we use rodent stroma to create a niche in which human stem cells are directed to become human prostatic epithelia. Task 1 sought to test if the rodent stromal niche (obtained after exposure to Vinclozolin) was altered so that differentiation and development to normal human prostate tissue was aberrant leading to a disease phenotype. Surprisingly, our results showed development of the prostatic phenotype was completely blocked and was not predicted. These novel findings are fundamental to understanding how normal prostatic differentiation proceeds and our publications show the essential role of stroma is perturbed by Vinclozolin, define the prostatic phenotype induced by Vinclozolin and demonstrate the involvement of NFkB signalling pathways.


Descriptors :   *PROSTATE CANCER , TISSUES(BIOLOGY) , FUNGICIDES , HUMAN BODY , STEM CELLS , CELLS(BIOLOGY) , PROSTATE GLAND , ANDROGENS , TEST AND EVALUATION , RODENTS


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE