Accession Number : ADA483242


Title :   Molecular Mechanism of Nkx3.1 Deregulation and its Function in Murine Pten Prostate Cancer Model


Descriptive Note : Annual summary 1 Sep 2004-31 Aug 2006


Corporate Author : CALIFORNIA UNIV LOS ANGELES


Personal Author(s) : Jiao, Jing


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a483242.pdf


Report Date : Sep 2006


Pagination or Media Count : 54


Abstract : Both PTEN and Nkx3.1 play important role in prostate cancer control. Preliminary results from Pten prostate model indicated that reduced Nkx3.1 expression is correlated with Cre-mediated Pten deletion. The goal of this study is to investigate how these two proteins interplay in prostate cancer development. We demonstrate that restoration of Nkx3.1 into Pten null prostate epithelium can lead to increases cell apoptosis, decreased cell proliferation and prevention of tumor initiation. The anti-tumor effect of Nkx3.1 is correlated with stabilization p53, inhibition Akt activation and AR function. This novel finding was published in Cancer cell. We generated and characterize the primary cell lines from Pten prostate cancer model, which will facilitate us to study the molecular mechanism of hormone refractory prostate cancer.


Descriptors :   *PROSTATE CANCER , HORMONES , MODELS , MOLECULES , PROTEINS , NEOPLASMS , NULLS(AMPLITUDE) , RESPONSE(BIOLOGY) , INHIBITION , CELLS(BIOLOGY) , PREVENTION , CANCER , PROSTATE GLAND , ACTIVATION , EPITHELIUM


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE