Accession Number : ADA482784


Title :   Radiation-Induced Immune Modulation in Prostate Cancer


Descriptive Note : Final rept. 1 Jan 2004-31 Dec 2007


Corporate Author : CALIFORNIA UNIV LOS ANGELES


Personal Author(s) : McBride, William H


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a482784.pdf


Report Date : Jan 2008


Pagination or Media Count : 72


Abstract : Radiotherapy is generally considered to be immunosuppressive, whereas we hypothesized that it modulates immune responses and has profound effects on the immune system rather than eliminating of lymphocytes. The goal of this study was to determine how radiation affects the presentation of prostate specific antigen (PSA), to investigate new potential mechanisms of altered immune function after radiation therapy, and to devise strategies to overcome radiation-induced immunosuppression in prostate cancer using treatment with IL-3 and/or GM-CSF. In addition, because of the high risk nature of the experiments and the high PSA expression levels in prostate cancer patients that might interfere with its efficacy, we developed a second model using survivin as an antigen, since it also is over-expressed in prostate and other cancers.


Descriptors :   *PROSTATE CANCER , *RADIATION , *ANTIGENS , *RADIATION EFFECTS , RADIOTHERAPY , PROSTATE GLAND , CYTOKINES , CELLS(BIOLOGY) , STRATEGY , IMMUNOSUPPRESSION


Subject Categories : Medicine and Medical Research
      Biochemistry


Distribution Statement : APPROVED FOR PUBLIC RELEASE