Accession Number : ADA482707


Title :   An Evaluation of Blood Cholinesterase Testing Methods for Military Health


Descriptive Note : Technical rept. Jul 2007-Feb 2008


Corporate Author : ARMY CENTER FOR ENVIRONMENTAL HEALTH RESEARCH FORT DETRICK MD


Personal Author(s) : Knechtges, Paul L


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a482707.pdf


Report Date : May 2008


Pagination or Media Count : 50


Abstract : Blood cholinesterase (ChE) testing is done to evaluate potential human exposure to chemicals that act as ChE-inhibitors, most often organophosphate and carbamates pesticides. The Model 400 Test-mate ChE kit (EQM Research, Inc.) is used for field blood ChE analysis within the Department of Defense. Suggested modifications to the Model 400 kit include displaying and recording acetyl-ChE activity uncorrected for temperature and using analytical standards for calibration or quality assurance purposes. The recent advent of a wide array of point of care devices may provide an opportunity for developing improved hand-held instruments field ChE analysis. If a hand-held device for field blood ChE analysis is developed for military health surveillance, a concept of operations for the device should be prepared as a first step. Some key performance areas for a field ChE device development are identified.


Descriptors :   *BLOOD ANALYSIS , *CHOLINESTERASE , QUALITY ASSURANCE , EXPOSURE(PHYSIOLOGY) , HAND HELD , ORGANOPHOSPHATES , PESTICIDES , CARBAMATES , HEALTH , DEPARTMENT OF DEFENSE , ACETYLCHOLINESTERASE


Subject Categories : Biochemistry
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE